Chemical Name: N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Biological ActivitySF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor.
Le et al.
BMB Rep., 2017;50:329
Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.
Citation for SF 1670
The citations listed below are publications that use Tocris products. Selected citations for SF 1670 include:
1 Citation: Showing 1 - 1
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity.
Authors: Lei Et al.
J Cell Biol 2017;216:2551
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