PTEN inhibitor. Increases fMLP-elicited PIP3
signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro
. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice.
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Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.