SGC 3027

Tocris Bioscience | Catalog # 6825

Potent and selective PRMT7 inhibitor
Tocris Bioscience
Discontinued Product
6825 has been discontinued. View all Protein Arginine Methyltransferase Inhibitors products.

Key Product Details

Description

Potent and selective PRMT7 inhibitor
View all Protein Arginine Methyltransferase Inhibitors »

Product Description

SGC 3027 is a potent and selective PRMT7 inhibitor (IC50 < 2.5 nM); pro-drug of SGC 8158. Methylates H2B (23-37). Exhibits > 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits methylation of HSP70 in C2C12 cells.

Negative control, SGC 3027N (Cat. No. 6838) also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.

Product Specifications for SGC 3027

Molecular Weight

787.37

Formula

C41H47ClN6O6S

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

N-(4-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

CAS Number

2624313-13-7

PubChem ID

137333447

InChI Key

MLJVGAYSVYMPSB-MSUKGTQXSA-N

SMILES

ClC1=CC=C(C2=CC(CN(CCCCSC[C@H]3O[C@@H](N4C=NC5=C4N=CN=C5N)[C@H](O)[C@@H]3O)C(CC(C6=C(C)C(C(C)=C(C)C6=O)=O)(C)C)=O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.74 100

Preparing Stock Solutions for SGC 3027

The following data is based on the product molecular weight 787.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.35 mL 12.70 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SGC 3027

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SGC 3027

For research use only

Related Research Areas

Epigenetics

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