DNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC50
values are 7.5, 8 and 12.5 μ
M with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.
Soluble to 50 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
Datta et al.
Cancer Res., 2009;69:4277
Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line.
Garc?a-Dom?nguez et al.