SGI 1027

Key Product Details

Product Description

SGI 1027 is a DNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC₅₀ values are 7.5, 8 and 12.5 μM with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation.

Product Specifications for SGI 1027

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SGI 1027

The following data is based on the product molecular weight 461.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.33 mL	21.67 mL	43.34 mL
2.5 mM	0.87 mL	4.33 mL	8.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
25 mM	0.09 mL	0.43 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• García-Domínguez Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line. Bioorg.Med.Chem.Lett. 2013 PMID: 23402879
• Datta A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 2009 PMID: 19417133

Product Documents for SGI 1027