Catalog Number: 1148
Chemical Name: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
Biological Activity
Phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).
Technical Data
  • M.Wt:
    284.32
  • Formula:
    C14H16N6O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    115344-47-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors.
    Tang et al.
    Eur.J.Pharmacol., 1994;268:105
  2. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185
  3. Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits.
    Freitag et al.
    Eur.J.Pharmacol., 1998;354:67

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