Siguazodan

Key Product Details

Product Description

Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC₅₀ = 117 nM).

Product Specifications for Siguazodan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Siguazodan

The following data is based on the product molecular weight 284.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tang Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 1994 PMID: 7925608
• Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.
• Freitag Phosphodiesterase inhibitors suppress &#945₂-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits. Eur.J.Pharmacol. 1998 PMID: 9726632

Product Documents for Siguazodan