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Siguazodan

1148 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1148/10
1148/50
Siguazodan | CAS No. 115344-47-3 | Phosphodiesterase Inhibitors
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Description: PDE3 inhibitor

Chemical Name: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine

Purity: ≥99%

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Biological Activity

Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM).

Technical Data

M.Wt:
284.32
Formula:
C14H16N6O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
115344-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits.
    Freitag et al.
    Eur.J.Pharmacol., 1998;354:67
  2. Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors.
    Tang et al.
    Eur.J.Pharmacol., 1994;268:105
  3. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185

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