Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one hydrochloride
Biological ActivityNatural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell Stem Cell, 2008;2(6):602-12.
Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.
Acta Med.Okayama, 1976;30:1
Activation of opioid μ-receptor by sinomenine in cell and mice.
Wang et al.
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
Qian et al.
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