Sinomenine hydrochloride

Catalog # Availability Size / Price Qty
3848/50
Sinomenine hydrochloride | CAS No. 6080-33-7 | Histaminergic-Related Compounds
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Description: Anti-inflammatory; causes mast cell degranulation and histamine release

Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one hydrochloride

Purity: ≥98%

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Biological Activity

Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.

Technical Data

M.Wt:
365.85
Formula:
C19H23NO4.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
6080-33-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008;2(6):602-12.
  2. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.
    Yamasaki
    Acta Med.Okayama, 1976;30:1
  3. Activation of opioid μ-receptor by sinomenine in cell and mice.
    Wang et al.
    Neurosci.Lett., 2008;443:209
  4. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
    Qian et al.
    J.Neuroinflamm., 2007;4:23

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