Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ
-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro
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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Desbordes SC, Placantonakis DG, Ciro A et al.
Cell Stem Cell.
Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.
Acta Med.Okayama, 1976;30:1
Activation of opioid μ-receptor by sinomenine in cell and mice.
Wang et al.
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
Qian et al.