SKF 77434 hydrobromide

Name: SKF 77434 hydrobromide
Brand: Tocris Bioscience
SKU: 1662
Price: 99 USD

Catalog #: 1662 Datasheet / COA / SDS

Discontinued Product

1662 has been discontinued.

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SKF 77434 hydrobromide | CAS No. 300561-58-4 | Dopamine D1 and D5 Receptor Agonists

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Description: Selective D1-like partial agonist

Chemical Name: 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide

Purity: ≥99%

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SKF 77434 hydrobromide is a selective dopamine D₁-like receptor partial agonist (IC₅₀ values are 19.7 and 2425 nM for binding to D₁-like and D₂-like receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:

376.29

Formula:

C₁₉H₂₁NO₂.HBr

Solubility:

Soluble to 10 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

300561-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from GlaxoSmithKline

Background References

Activation of the 5-HT_1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393.
Briggs et al.
Br.J.Pharmacol., 1991;104:1038
DA D₁ receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats.
Meyer and Schults
Pharmacol.Biochem.Behav., 1993;46:269
Stereoisomeric probes for the D₁ DA receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.
Neumeyer et al.
J.Med.Chem., 1992;35:1466

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