SNS 314 mesylate
1 Image
Description: Potent pan-Aurora kinase inhibitor
Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate
Biological Activity
Potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).Technical Data
Formula:
C18H15ClN6OS2.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1146618-41-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo.
Arbitrario et al.
Cancer Chemother. Pharmacol., 2010;65:707 -
The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model.
VanderPorten et al.
Mol.Cancer Ther., 2009;8:930 -
Discovery of a potent and selective Aurora kinase inhibitor.
Oslob et al.
Bioorg.Med.Chem.Lett., 2008;18:4880
Product Datasheets
Reconstitution Calculator
Reconstitution Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SNS 314 mesylate
There are currently no reviews for this product. Be the first to review SNS 314 mesylate and earn rewards!
Have you used SNS 314 mesylate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive tools for
life science research with over 30 years' experience in the industry.
Tocris is a Bio-Techne brand.
