SNS 314 mesylate

Catalog # Availability Size / Price Qty
4584/10
4584/50
Cat.No. 4584 - SNS 314 mesylate | C18H15ClN6OS2.CH3SO3H | CAS No. 1146618-41-8
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Description: Potent pan-Aurora kinase inhibitor

Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate

Product Details
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Biological Activity

Potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).

Technical Data

Formula:
C18H15ClN6OS2.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1146618-41-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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