Carboplatin

Tocris Bioscience | Catalog # 2626

DNA cross-linking antitumor agent
Tocris Bioscience

Key Product Details

Description

DNA cross-linking antitumor agent

Alternative Names

NSC 241240,Paraplatin,JM 8
View all Apoptosis Inducer Compounds »

Product Description

Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

Product Specifications for Carboplatin

Molecular Weight

371.25

Formula

C6H12N2O4Pt

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

CAS Number

41575-94-4

PubChem ID

10339178

InChI Key

OLESAACUTLOWQZ-UHFFFAOYSA-L

SMILES

O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.28 25

Preparing Stock Solutions for Carboplatin

The following data is based on the product molecular weight 371.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.77 mL 53.87 mL 107.74 mL
1.25 mM 2.15 mL 10.77 mL 21.55 mL
2.5 mM 1.08 mL 5.39 mL 10.77 mL
12.5 mM 0.22 mL 1.08 mL 2.15 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for Carboplatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Carboplatin

For research use only

⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Carboplatin (1)

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  • Anti-tumor activity assay
    Name: Donghee Choi
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 01/04/2018
    Used in in vitro assay to assess anti-tumor activity in combination with other agents

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