Catalog Number: 2626
Alternate Names: NSC 241240, Paraplatin, JM 8
Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Biological Activity
Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).
Technical Data
  • M.Wt:
    371.25
  • Formula:
    C6H12N2O4Pt
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    41575-94-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited.
    Natarajan et al.
    Biochem.Pharmacol., 1999;58:1625
  2. High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity.
    Thomas et al.
    Mol.Pharmacol., 2006;70:23
  3. Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks.
    Yang et al.
    Radiation Res., 1995;143:302
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Carboplatin include:

2 Citations: Showing 1 - 2
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  1. Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
    Authors: Massey
    PLoS One 2015;10:e0134306
  2. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
    Authors: Bryant Et al.
    Cell Death Differ 2014;14:570

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