Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Biological ActivityCarboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited.
Natarajan et al.
Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks.
Yang et al.
Radiation Res., 1995;143:302
High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity.
Thomas et al.
Citations for Carboplatin
The citations listed below are publications that use Tocris products. Selected citations for Carboplatin include:
3 Citations: Showing 1 - 3
Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines.
Authors: Ishiguro Et al.
J Transl Sci 2016;2:117
Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
PLoS One 2015;10:e0134306
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
Authors: Bryant Et al.
Cell Death Differ 2014;14:570
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Used in in vitro assay to assess anti-tumor activity in combination with other agents