Chemical Name: (2E,4E)-2,4-Hexenoic acid
Biological ActivitySorbic acid is an activator of hFFA2-DREADDs. Inhibits forskolin-induced cAMP production (IC50 ∼ 1 μM) and promotes accumulation of inositol monophosphates (IC50 >1 μM) in cells expressing hFFA2-DREADD. Promotes the release of GLP-1 from colonic crypts derived from hFFA2-DREADD-expressing mice.
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Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Bolognini et al.
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