Catalog Number: 0631
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Biological Activity
5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.
Technical Data
  • M.Wt:
    379.46
  • Formula:
    C22H25N3O3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    1054-88-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.
    Bylund et al.
    Mol.Pharmacol., 1992;42:1
  2. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.
    Schoeffter and Hoyer
    Br.J.Pharmacol., 1988;95:975
  3. Spiroxatrine: a selective serotonin 1A receptor antagonist.
    Nelson and Taylor
    Eur.J.Pharmacol., 1986;124:207
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Spiroxatrine include:

1 Citations: Showing 1 - 1

  1. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
    Authors: Moura Et al.
    Br J Pharmacol 2006;149:1049

Have you used Spiroxatrine?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Feedback

Customer Information