Catalog Number: 0631
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Biological Activity
5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.
    Bylund et al.
    Mol.Pharmacol., 1992;42:1
  2. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.
    Schoeffter and Hoyer
    Br.J.Pharmacol., 1988;95:975
  3. Spiroxatrine: a selective serotonin 1A receptor antagonist.
    Nelson and Taylor
    Eur.J.Pharmacol., 1986;124:207

The citations listed below are publications that use Tocris products. Selected citations for Spiroxatrine include:

Showing Results 1 - 1 of 1

  1. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
    Authors: Moura Et al.
    Br J Pharmacol
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