Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Biological ActivitySpiroxatrine is a 5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.
Bylund et al.
Spiroxatrine: a selective serotonin 1A receptor antagonist.
Nelson and Taylor
Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.
Schoeffter and Hoyer
Citation for Spiroxatrine
The citations listed below are publications that use Tocris products. Selected citations for Spiroxatrine include:
1 Citation: Showing 1 - 1
Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
Authors: Moura Et al.
Br J Pharmacol 2006;149:1049
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