SR 141716A

  ( 12 citations )    
Product Datasheet
Catalog Number:0923
Alternate Names:Rimonabant hydrochloride
Chemical Name:N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats.
Technical Data
  • M.Wt:
    500.25
  • Formula:
    C22H21Cl3N4O.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    158681-13-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 141716A include:

12 Citations: Showing 1 - 10
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  1. Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site.
    Authors: Klingerman Et al.
    Dose Response  2016;13:1559325815618910
  2. Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor.
    Authors: Hayase
    PLoS One  2016;11:e0158950
  3. Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats.
    Authors: Bruijnzeel Et al.
    PLoS One  2016;11:e0153327
  4. (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.
    Authors: Mahmoud Et al.
    Mol Pharmacol  2015;87:197
  5. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
    Authors: Tang and Alger
    J Neurosci  2015;35:3938
  6. Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
    Authors: Marcu Et al.
    J Pharmacol Exp Ther  2013;345:189
  7. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
    Authors: Sumislawski Et al.
    Neuropsychopharmacology  2011;36:2750
  8. Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
    Authors: Kapur Et al.
    J Pharmacol Exp Ther  2008;325:341
  9. Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
    Authors: Graham Et al.
    Br J Pharmacol  2006;281:29085
  10. Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
    Authors: Stanford Et al.
    Br J Pharmacol  2001;133:825
  11. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
    Authors: Martin Et al.
    Front Mol Neurosci  2000;129:1707
  12. Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors.
    Authors: MacLennan Et al.
    Br J Pharmacol  1998;124:619
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