SR 141716A

Catalog # Availability Size / Price Qty
0923/10
0923/50
Cat.No. 0923 - SR 141716A | C22H21Cl3N4O.HCl | CAS No. 158681-13-1
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Description: Selective CB1 inverse agonist
Alternative Names: Rimonabant hydrochloride

Chemical Name: N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

Product Details
Citations (14)
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Reviews

Biological Activity

Potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats.

Technical Data

Formula:
C22H21Cl3N4O.HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
158681-13-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for SR 141716A

The citations listed below are publications that use Tocris products. Selected citations for SR 141716A include:

14 Citations: Showing 1 - 10

  1. Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway.
    Authors: Jiang Et al.
    Br J Pharmacol  2017;174:177
  2. Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site.
    Authors: Klingerman Et al.
    Dose Response  2016;13:1559325815618910
  3. Putative Epigenetic Involvement of the Endocannabinoid System in Anxiety- and Depression-Related Behaviors Caused by Nicotine as a Stressor.
    Authors: Hayase
    PLoS One  2016;11:e0158950
  4. Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats.
    Authors: Bruijnzeel Et al.
    PLoS One  2016;11:e0153327
  5. (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.
    Authors: Mahmoud Et al.
    Mol Pharmacol  2015;87:197
  6. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
    Authors: Tang and Alger
    J Neurosci  2015;35:3938
  7. Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.
    Authors: Marcu Et al.
    J Pharmacol Exp Ther  2013;345:189
  8. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.
    Authors: Sumislawski Et al.
    Neuropsychopharmacology  2011;36:2750
  9. Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction.
    Authors: Kapur Et al.
    J Pharmacol Exp Ther  2008;325:341
  10. Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
    Authors: Graham Et al.
    Br J Pharmacol  2006;281:29085

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