SR 3677 dihydrochloride
Chemical Name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
Biological ActivitySR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.
Feng et al.
Citations for SR 3677 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SR 3677 dihydrochloride include:
2 Citations: Showing 1 - 2
A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
Authors: Lotz-Jenne Et al.
P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
Authors: El-Sayed Et al.
Front Microbiol 2014;307:C83
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