Catalog Number: 4337
Chemical Name: 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
Biological Activity
High affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
Technical Data
  • M.Wt:
    326.78
  • Formula:
    C13H17ClN2.C2H2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1210-81-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors.
    Riccioni et al.
    Eur.J.Pharmacol., 2011;661:8
  2. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist.
    Valentini et al.
    Neuropharmacology, 2011;60:602
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ST 1936 oxalate include:

1 Citations: Showing 1 - 1

  1. Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
    Authors: Yun Et al.
    Scientific Reports 2016;6:30985

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