Chemical Name: 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
Biological Activity High affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
Soluble to 100 mM in DMSO
Store at +4°C
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