ST 1936 oxalate
Chemical Name: 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
Biological ActivityST 1936 oxalate is a high affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors.
Riccioni et al.
A microdialysis study of ST1936, a novel 5-HT6 receptor agonist.
Valentini et al.
Citation for ST 1936 oxalate
The citations listed below are publications that use Tocris products. Selected citations for ST 1936 oxalate include:
1 Citation: Showing 1 - 1
Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
Authors: Yun Et al.
Scientific Reports 2016;6:30985
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