Catalog Number: 2638
Chemical Name: N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
Biological Activity
α2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.
Technical Data
  • M.Wt:
    253.77
  • Formula:
    C13H19N3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    4749-61-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats.
    Takano and Yaksh
    J.Pharmacol.Exp.Ther., 1992;261:764
  2. Synergistic interactions between two α2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats.
    Graham et al.
    Pain, 2000;85:135
  3. Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep.
    Celly et al.
    J.Pharmacol.Exp.Ther., 1999;289:712
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ST 91 include:

1 Citations: Showing 1 - 1

  1. Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
    Authors: Kim Et al.
    Brain Res 2011;1384:110

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