Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Biological ActivitySwainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II.
Tulsiani et al.
The potential importance of swainsonine in therapy for cancers and immunology.
Olden et al.
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.
Sun et al.
Citations for Swainsonine
The citations listed below are publications that use Tocris products. Selected citations for Swainsonine include:
3 Citations: Showing 1 - 3
N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors.
Authors: Skrenkova Et al.
Front Mol Neurosci 2018;11:188
Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.
Authors: Tareen Et al.
Mol Ther 2014;22:575
The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
Authors: Nacev Et al.
J Biol Chem 2011;286:44045
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