Catalog Number: 2518
Chemical Name: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Biological Activity
Selective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.
Technical Data
  • M.Wt:
    275.22
  • Formula:
    C13H18N2.2HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    787587-06-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.
    Marrero et al.
    J.Pharmacol.Exp.Ther., 2004;309:16
  2. Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes.
    Papke et al.
    Eur.J.Pharmacol., 2005;524:11

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