TC 1698 dihydrochloride

Key Product Details

Product Description

TC 1698 dihydrochloride is a selective nicotinic α7 receptor agonist (EC₅₀ = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.

Product Specifications for TC 1698 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TC 1698 dihydrochloride

The following data is based on the product molecular weight 275.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.63 mL	18.17 mL	36.33 mL
5 mM	0.73 mL	3.63 mL	7.27 mL
10 mM	0.36 mL	1.82 mL	3.63 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Papke Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 2005 PMID: 16266703
• Marrero The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 2004 PMID: 14722323

Product Documents for TC 1698 dihydrochloride