TC-E 5005
Chemical Name: 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
Purity: ≥99%
Biological Activity
TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Hofgen et al.
J.Med.Chem., 2010;53:4399
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Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.
