TC-E 5005

Catalog # Availability Size / Price Qty
4572/10
4572/50
Phosphodiesterase Inhibitors Small Molecule
1 Image
Description: Potent and selective PDE10A inhibitor

Chemical Name: 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Potent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.

Technical Data

M.Wt:
270.33
Formula:
C15H18N4O
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
959705-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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PDE inhibition assay in tissue culture
By Anonymous on 01/04/2018
Species: Human

Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.


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