Chemical Name: 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine
Biological ActivityPotent and selective PDE10A inhibitor (IC50 values are 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively and >5000 nM at PDE1B, 4A, 6, 8A and 9A). Reverses MK 801-induced hyperactivity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Hofgen et al.
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Dosed product into cell culture media to final concentration of 10uM and at various time points up to 72h and isolated RNA from cells for downstream qPCR analysis to review effect of PDE inhibition on cell line phenotype.