TC HSD 21
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Description: Potent and selective 17β-hydroxysteroid dehydrogenase type 3 inhibitor
Chemical Name: 5-[(3-Bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone
Purity: ≥99%
Biological Activity
Potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Displays no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors.Technical Data
M.Wt:
422.32
Formula:
C17H12BrNO3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
330203-01-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors.
Harada et al.
Bioorg.Med.Chem.Lett., 2012;22:504
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