Potent and selective mGlu4
receptor positive allosteric modulator (EC50
= 9 nM in human mGlu4
-expressing BHK cells). Selective for mGlu4
values are > 10 μ
M). Brain penetrant.
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.
Hong et al.