Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki
values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μ
M for PTP1B, CD45 D1D2, PTPβ
D1, SHP-1, PTPα
D1 and LAR D1D2 respectively).
Soluble to 25 mM in DMSO
Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
Iversen et al.
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Andersen et al.
The citations listed below are publications that use Tocris products. Selected citations for TCS 401 include:
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