Catalog Number: 2754
Chemical Name: 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
Biological Activity
Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
Technical Data
  • M.Wt:
    306.72
  • Formula:
    C10H10N2O5S.HCl
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    243966-09-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
    Iversen et al.
    J.Biol.Chem., 2000;275:10300
  2. Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
    Andersen et al.
    J.Med.Chem., 2002;45:4443
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TCS 401 include:

1 Citations: Showing 1 - 1

  1. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
    Authors: Du Et al.
    J Neurosci 2015;21:523

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