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Telaprevir

Catalog #: 6658 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6658/50
6658/10
Telaprevir | CAS No. 402957-28-2 | Additional Synthetic Protease Inhibitors
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Description: Hepatitis C virus (HCV) protease NS3/4A inhibitor
Alternative Names: VX-950, LY-570310

Chemical Name: (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide

Purity: ≥98%

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Biological Activity

Telaprevir is a hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.

Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.

Technical Data

M.Wt:
679.85
Formula:
C36H53N7O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
402957-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
    Jacobs et al.
    Nat.Methods, 2018;15:523

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