Chemical Name: N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Biological ActivitySelective TASK3 activator (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
Petranyi et al.
Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.
Wright et al.
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