Terbinafine hydrochloride

Key Product Details

Product Description

Terbinafine hydrochloride is a selective TASK3 activator (pEC₅₀ = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Product Specifications for Terbinafine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Terbinafine hydrochloride

The following data is based on the product molecular weight 327.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.25 mL	30.50 mL
5 mM	0.61 mL	3.05 mL	6.10 mL
10 mM	0.30 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wright Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 2017 PMID: 28882594
• Petranyi Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 1984 PMID: 6547247

Product Documents for Terbinafine hydrochloride