Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo
. Promotes self-renewal of human embryonic stem cells (hESC).
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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Desbordes SC, Placantonakis DG, Ciro A et al.
Cell Stem Cell.
Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors.
Kakuda et al.
Theanine prevents memory impairment induced by repeated cerebral ischemia in rats.
Egashira et al.
Possible involvement of group I mGluRs in neuroprotective effect of theanine.
Nagasawa et al.