Tipifarnib

Catalog # Availability Size / Price Qty
6410/25
6410/5
Tipifarnib | CAS No. 192185-72-1 | Protein Prenyltransferase Inhibitors
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Description: Potent farnesyltransferase inhibitor; orally bioavailable

Chemical Name: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone

Purity: ≥98%

Product Details
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Biological Activity

Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.

Technical Data

M.Wt:
489.4
Formula:
C27H22Cl2N4O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
192185-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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