Tipifarnib

Key Product Details

Product Description

Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC₅₀ values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.

Product Specifications for Tipifarnib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tipifarnib

The following data is based on the product molecular weight 489.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.22 mL	20.43 mL
5 mM	0.41 mL	2.04 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• End Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001 PMID: 11196150

Product Documents for Tipifarnib