Biological ActivityTissue Clearing Pro is a rapid, easy-to-use, reversible and non-destructive clearing and staining kit, which allows effective tissue clearing and staining of whole tissues. Tissue Clearing Pro is a solvent based tissue clearing technique, comparable to BABB and DISCO. Tissue Clearing Pro-Organoid does not cause significant shrinkage or tissue damage and does not use as harsh a solvent as other solvent based techniques.
This kit can clear a whole mouse brain of up to 8 mm thickness in 24 hours; for sections with a thickness of 1 mm this can be achieved in 2 hours. Tissue Clearing Pro is compatible with fluorescent protein, immunolabeling and small molecule staining techniques, as well as being suitable for use with all standard dyes and buffers. Following 3D imaging, Tissue Clearing Pro can be reversed for follow-up 2D histology staining. The kit comes with a getting started guide and a more comprehensive tissue clearing guidebook, providing detailed protocols. The Tissue Clearing Pro kit contains 30 mL of Tissue Clearing Pro clearing reagent 1 and 2, plus the 5 buffer solutions required to process tissues for immunolabeling, and is enough to process four whole mouse brains (approx. 2 g of tissue).
Please read the Tissue Clearing Pro Guidebook for more information and detailed protocols for using this kit.
Guidebook and ProtocolFor information on how to use Tissue Clearing Pro download our Guidebook.
A wide range of IHC validated antibodies are available from R&D Systems and Novus Biologicals; optimization of antibody incubation conditions for use with the Tissue Clearing Pro technique is recommended.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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