Tocriscreen Kinase Inhibitor 3.0
Tocris Bioscience | Catalog # 7844
Key Product Details
Description
Key Format Details
- 96-well racks with TrakMate tubes & SepraSeal caps
- Pre-dissolved in DMSO
- Compounds arranged 80 per rack with 3 racks per library
- Many compounds are exclusive to Tocris
- Full chemical and biological data available
- Exceptional purity
Major IUPHAR kinase subfamilies covered by Tocriscreen Kinase Inhibitor 3.0 Library. TK (tyrosine kinase, 29%); CMGC (includes CDK, MAPK, GSK3 and CLK families, 19%); TKL (tyrosine kinase-like, 16%); AGC (includes PKA, PKG and PKC families, 11%); Atypical (7%); CAMK, (calcium/calmodulin-dependent protein kinases, 4%) and Other Kinases (includes CAMKK, CK1 and STE, 14%).
Product Description
Tocriscreen Kinase Inhibitor 3.0 compound library is a collection of 210 kinase inhibitors supplied pre-dissolved in DMSO (100 μL 10 mM solution). The Tocriscreen Kinase Inhibitor 3.0 Library contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR and AKT, as well as novel targets such as Haspin and DYRK. The Tocriscreen Kinase Inhibitor 3.0 library is suitable for high-throughput screening (HTS), cell based high-content screening (HCS), target validation and assay development. Please view the kinase tree image for a closer look at the pharmacological diversity of this compound library.Scientific Data Images for Tocriscreen Kinase Inhibitor 3.0
Kinase phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen Kinase Inhibitor 3.0 Library.
The 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library target over 230 kinases. Targets are evenly spread across all the major IUPHAR kinase subfamilies, with a mix of well-established targets such as VEFGR and AKT, and “dark” kinases such as CDK19 and DYRK1B. To view a larger PDF version of this image, please click on the 'kinase tree' link in the product description.
Chemical diversity of the Tocriscreen Kinase Inhibitor 3.0 compound library.
The images show the overlapping chemical space of the 210 compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library (green dots) in relation to the chemical space occupied by the ChEMBL kinase inhibitors (grey dots). Each dot represents a unique fingerprint generated from each compound's 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen Kinase Inhibitor 3.0 compound library highlights the chemical diversity of this library.
Product Specifications for Tocriscreen Kinase Inhibitor 3.0
Storage
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 46 publications citing the usage of this product.
There are currently no references for this product.
Product Documents for Tocriscreen Kinase Inhibitor 3.0
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Tocriscreen Kinase Inhibitor 3.0
For research use only
Citations for Tocriscreen Kinase Inhibitor 3.0
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