Trazodone hydrochloride

Key Product Details

Product Description

Trazodone hydrochloride is a 5-HT_2A and α₁ adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.

Product Specifications for Trazodone hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Trazodone hydrochloride

The following data is based on the product molecular weight 408.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.90 mL	24.49 mL	48.98 mL
2.5 mM	0.98 mL	4.90 mL	9.80 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Halliday Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 2017 PMID: 28430857
• Bortolotto Proneurogenic effects of traz. in murine and human neural progenitor cells. ACS Chem.Neurosci. 2017 PMID: 28636360

Product Documents for Trazodone hydrochloride