Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
Biological ActivityTrazodone hydrochloride is a 5-HT2A and α1 adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Halliday et al.
Proneurogenic effects of traz. in murine and human neural progenitor cells.
Bortolotto et al.
ACS Chem.Neurosci., 2017;8:2027
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