TT 232

Name: TT 232
Brand: Tocris Bioscience
SKU: 4639

Tocris Bioscience | Catalog # 4639

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Product Documents

sst1 and sst4 agonist

Discontinued Product

4639 has been discontinued. View all Somatostatin Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

sst1 and sst4 agonist

View all Somatostatin Receptor Agonists »

Product Description

TT 232 is a peptide agonist for sst₁/sst₄ somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.

Product Specifications for TT 232

Molecular Weight

947.13

Formula

C₄₅H₅₈N₁₀O₉S₂

Storage

Store at -20°C

CAS Number

147159-51-1

PubChem ID

6918265

InChI Key

SNAJPQVDGYDQSW-DYCFWDQMSA-N

SMILES

[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Kéri A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8901613
Elekes Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 2008 PMID: 17961545
Tejeda Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 2006 PMID: 17094470

Product Documents for TT 232

Certificate of Analysis

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Product Specific Notices for TT 232

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

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