Biological ActivityPeptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.
(Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models.
Tejeda et al.
Anticancer Res., 2006;26:3477
A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity.
Kéri et al.
Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse.
Elekes et al.
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