Tubastatin A hydrochloride

Catalog # Availability Size / Price Qty
6270/10
Tubastatin A hydrochloride | CAS No. 1310693-92-5 | Class II Histone Deacetylases Inhibitors
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Description: Potent HDAC6 inhibitor

Chemical Name: N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC50 = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC50 values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.

Technical Data

M.Wt:
371.86
Formula:
C20H21N3O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1310693-92-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
    Butler et al.
    J.Am.Chem.Soc., 2010;132:10842
  2. HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
    d'Ydewalle et al.
    Nature medicine, 2011;7:26

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