Tubastatin A hydrochloride

Key Product Details

Product Description

Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC₅₀ = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC₅₀ values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.

Product Specifications for Tubastatin A hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tubastatin A hydrochloride

The following data is based on the product molecular weight 371.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.89 mL	134.46 mL	268.92 mL
0.5 mM	5.38 mL	26.89 mL	53.78 mL
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• d'Ydewalle HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nature medicine 2011 PMID: 21785432
• Butler Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J.Am.Chem.Soc.

Product Documents for Tubastatin A hydrochloride