Catalog Number: 4133
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Biological Activity
Analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data
  • M.Wt:
    466.66
  • Formula:
    C29H42N2O3
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    142878-12-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.
    Muto et al.
    J.Pharmacol.Exp.Ther., 1997;282:1379
  2. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT.
    Kataoka et al.
    J.Neurochem., 2009;108:115
  3. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
    Ma et al.
    J.Pharmacol.Exp.Ther., 2009;328:409
  4. Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow.
    Berven and Barritt
    Biochem.Pharmacol., 1995;49:1373
Citations:

The citations listed below are publications that use Tocris products. Selected citations for U 73343 include:

7 Citations: Showing 1 - 7
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  1. Detachment of surface membrane invagination systems by cationic amphiphilic drugs.
    Authors: Osman Et al.
    PLoS One 2016;6:18536
  2. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci 2015;35:11252
  3. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells.
    Authors: Yoon Et al.
    Sci Rep 2015;2015:843024
  4. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    PLoS One 2015;10:e0140369
  5. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Cereb Blood Flow Metab 2015;10:e0124986
  6. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One 2014;9:e106316
  7. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
Tocris Small Molecules
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U 73122

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