Catalog Number: 4133
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Biological Activity
Analog of U 73122 (Cat. No. 1268); can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.
    Muto et al.
    J.Pharmacol.Exp.Ther., 1997;282:1379
  2. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT.
    Kataoka et al.
    J.Neurochem., 2009;108:115
  3. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
    Ma et al.
    J.Pharmacol.Exp.Ther., 2009;328:409
  4. Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow.
    Berven and Barritt
    Biochem.Pharmacol., 1995;49:1373
Tocris Small Molecules
Description Application Cat# Citations Images  

U 73122

1268 47  
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