U 73343

Catalog # Availability Size / Price Qty
4133/10
4133/50
Phospholipase Inhibitors Small Molecule
1 Image
Description: Analog of U 73122 (Cat. No. 1268)

Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data

M.Wt:
466.66
Formula:
C29H42N2O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
142878-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for U 73343

The citations listed below are publications that use Tocris products. Selected citations for U 73343 include:

12 Citations: Showing 1 - 10

  1. IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
    Authors: Atakpa Et al.
    Cell Rep  2018;25:3180
  2. A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.
    Authors: Rajan Et al.
    Dev Cell  2017;43:83
  3. Detachment of surface membrane invagination systems by cationic amphiphilic drugs.
    Authors: Osman Et al.
    PLoS One  2016;6:18536
  4. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  5. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells.
    Authors: Yoon Et al.
    Sci Rep  2015;2015:843024
  6. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    PLoS One  2015;10:e0140369
  7. DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Cereb Blood Flow Metab  2015;10:e0124986
  8. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  9. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
    Authors: Ruisanchez Et al.
    FASEB J  2014;28:880
  10. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
    Authors: Brenner Et al.
    Pain  2014;155:2124

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