U 73343

Catalog # Availability Size / Price Qty
4133/10
4133/50
Cat.No. 4133 - U 73343 | C29H42N2O3 | CAS No. 142878-12-4
1 Image
Description: Analog of U 73122 (Cat. No. 1268)

Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione

Purity: ≥98%

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

Analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data

M.Wt:
466.66
Formula:
C29H42N2O3
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
142878-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

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Citations for U 73343

The citations listed below are publications that use Tocris products. Selected citations for U 73343 include:

10 Citations: Showing 1 - 10

  1. Detachment of surface membrane invagination systems by cationic amphiphilic drugs.
    Authors: Osman Et al.
    PLoS One  2016;6:18536
  2. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  3. The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells.
    Authors: Yoon Et al.
    Sci Rep  2015;2015:843024
  4. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    PLoS One  2015;10:e0140369
  5. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    J Cereb Blood Flow Metab  2015;10:e0124986
  6. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  7. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.
    Authors: Ruisanchez Et al.
    FASEB J  2014;28:880
  8. A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.
    Authors: Brenner Et al.
    Pain  2014;155:2124
  9. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
    Authors: Zhao
    J Neurophysiol  2014;111:1008
  10. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123

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