Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50
values of 1-5 μ
M. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50
< 50 nM) and exhibits antinociceptive activity in vivo
. Also activates TRPM4 and inhibits TRPM3 channels. Negative control U 73343
(Cat. No. 4133) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Pharmacia
Other Product-Specific Information:
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.
Bleasdale et al.
U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions.
Smith et al.
Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.
Shi et al.
Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122.
Leitner et al.
The citations listed below are publications that use Tocris products. Selected citations for U 73122 include:
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