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U 89843A

2734 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2734/10
2734/50
U 89843A | CAS No. 157013-85-9 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA receptors
Alternative Names: PNU 89843

Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride

Purity: ≥99%

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Biological Activity

Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.

Technical Data

M.Wt:
321.85
Formula:
C16H23N5.HCl
Solubility:
Soluble to 25 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
157013-85-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human GABA-A R alpha 1 (NP_000797) VersaClone cDNA

RDC0689

Human GABA-A R rho 1 (NP_002033) VersaClone cDNA

RDC0262

Human GABA-A R gamma 2 (NP_944493) VersaClone cDNA

RDC1243

Human GABA-A R beta 2 (NP_000804) VersaClone cDNA

RDC0849

Human GABA-A R alpha 4 (NP_000800) VersaClone cDNA

RDC0872

Human GABA-A R epsilon (NP_004952) VersaClone cDNA

RDC1222

Human GABA-A R beta 3 (NP_000805) VersaClone cDNA

RDC0835

Human GABA-A R beta 3 (NP_068712) VersaClone cDNA

RDC0836

Human GABA-A R alpha 6 (NP_000802) VersaClone cDNA

RDC0827

Human GABA-A R alpha 2 (NP_000798) VersaClone cDNA

RDC0690

Human GABA-A R gamma 1 (NP_775807) VersaClone cDNA

RDC1125

Human GABA-A R gamma 2 (NP_944494) VersaClone cDNA

RDC1126

Human GABA-A R gamma 3 (NP_000807) VersaClone cDNA

RDC1127

Human GABA-A R gamma 2 (NP_000807) VersaClone cDNA

RDC1151

Human GABA-A R rho 3 (NP_001099050) VersaClone cDNA

RDC0966

Human GABA-A R delta (NP_000806) VersaClone cDNA

RDC1047

Human GABA-A R alpha 5 (NP_000801) VersaClone cDNA

RDC0899

Human GABA-A R rho 2 (P28476) VersaClone cDNA

RDC0271

Human GABA-A R alpha 3 (NP_000799) VersaClone cDNA

RDC0691

Human GABA-A R theta (AAF70380) VersaClone cDNA

RDC0218

Human GABA-A R beta 1 (NP_000803) VersaClone cDNA

RDC0852

Human GABA-A R beta 2 (NP_068711) VersaClone cDNA

RDC0883

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