Positive allosteric modulator of GABAA
receptors. Enhances GABA-induced Cl-
currents in the α1β2γ2
subtypes. Causes sedation in vivo
following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors.
Haesook et al.
Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals.
Rohn et al.
Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity.
Bundy et al.