Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Biological ActivityU 89843A is a positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
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Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity.
Bundy et al.
U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors.
Haesook et al.
Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals.
Rohn et al.
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