U 89843A
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Purity: ≥99%
Biological Activity
U 89843A is a positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity.
Bundy et al.
J.Med.Chem., 1995;38:4161 -
U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors.
Haesook et al.
J.Pharmacol.Exp.Ther., 1995;275:1390 -
Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals.
Rohn et al.
Biochem.Pharmacol., 1996;51:471
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