U 89843A
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Purity: ≥99%
Biological Activity
U 89843A is a positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity.
Bundy et al.
J.Med.Chem., 1995;38:4161 -
U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors.
Haesook et al.
J.Pharmacol.Exp.Ther., 1995;275:1390 -
Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals.
Rohn et al.
Biochem.Pharmacol., 1996;51:471
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for U 89843A
There are currently no reviews for this product. Be the first to review U 89843A and earn rewards!
Have you used U 89843A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
