Catalog Number: 2734
Alternate Names: PNU 89843
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Biological Activity
Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors.
    Haesook et al.
    J.Pharmacol.Exp.Ther., 1995;275:1390
  2. Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals.
    Rohn et al.
    Biochem.Pharmacol., 1996;51:471
  3. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity.
    Bundy et al.
    J.Med.Chem., 1995;38:4161
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