Catalog Number: 1348
Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Biological Activity
Subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.
Technical Data
  • M.Wt:
    350.8
  • Formula:
    C13H15ClN2.C4H4O4
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    200432-86-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Bristol
Background References
  1. Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release.
    Cao et al.
    Neuropharmacology, 2005;48:72
  2. UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes.
    Sharples et al.
    J.Neurosci., 2000;20:2783
  3. Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid.
    Wright et al.
    Bioorg.Med.Chem.Lett., 1997;7:2867

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