UB 165 fumarate

Key Product Details

Product Description

UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. K_i values are 0.27, 20 (IC₅₀), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

Licensing Information

Sold with the permission of the University of Bristol

Product Specifications for UB 165 fumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UB 165 fumarate

The following data is based on the product molecular weight 350.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.25 mL	28.51 mL
5 mM	0.57 mL	2.85 mL	5.70 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wright Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett.
• Cao Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 2005 PMID: 15617729
• Sharples UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 2000 PMID: 10751429

Product Documents for UB 165 fumarate