Subtype-selective nicotinic agonist. Full agonist at α
2- and very weak partial agonist at α
2- containing nAChRs. Ki
values are 0.27, 20 (IC50
), 2790 and 990 nM for α
7 and α
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Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release.
Cao et al.
UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes.
Sharples et al.
Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid.
Wright et al.