UBP1112
Chemical Name: α-Methyl-3-methyl-4-phosphonophenylglycine
Purity: ≥99%
Biological Activity
UBP1112 is an a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
Conway et al.
Bioorg.Med.Chem.Lett., 2001;11:777 -
Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.
Miller et al.
Br.J.Pharmacol., 2003;139:1523
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Citations for UBP1112
The citations listed below are publications that use Tocris products. Selected citations for UBP1112 include:
2 Citations: Showing 1 - 2
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Group III metabotropic glutamate receptors and transient receptor potential vanilloid 1 co-localize and interact on nociceptors.
Authors: Govea Et al.
J Biol Chem 2012;217:130
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Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Authors: Proudfoot Et al.
Curr Biol 2006;16:1591
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