UNC 1215

Catalog # Availability Size / Price Qty
4666/10
4666/50
Cat.No. 4666 - UNC 1215 | C32H43N5O2
1 Image
Description: Potent inhibitor of L3MBTL3 Kme reader domain; cell permeable

Chemical Name: 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide

Purity: ≥99%

Product Details
Reviews

Biological Activity

Potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1215 is reviewed on the chemical probes website.

Technical Data

M.Wt:
529.72
Formula:
C32H43N5O2
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in 2eq.HCl
Purity:
≥99%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary on the SGC website.

Background References

  1. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
    James et al.
    Nat.Chem.Biol. [Epub ahead of print], 2013;

Product Datasheets

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