Chemical Name: 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide
Biological ActivityPotent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
James et al.
Nat.Chem.Biol. [Epub ahead of print], 2013;
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