Potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50
= 40 nM; Kd
= 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary
on the SGC website.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
James et al.
Nat.Chem.Biol. [Epub ahead of print], 2013;