UNC 1215

Discontinued Product

4666 has been discontinued.
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UNC 1215 | Other Epigenetics Compounds
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Description: Potent inhibitor of L3MBTL3 Kme reader domain; cell permeable

Chemical Name: 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide

Purity: ≥99%

Product Details

Biological Activity

UNC 1215 is a potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1215 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in 2eq.HCl
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary on the SGC website.

Background References

  1. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
    James et al.
    Nat.Chem.Biol. [Epub ahead of print], 2013;

Product Datasheets

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