UNC 2327

Catalog # Availability Size / Price Qty
5057/10
5057/50
Cat.No. 5057 - UNC 2327 | C14H17N5O2S | CAS No. 1426152-53-5
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Description: Allosteric inhibitor of PRMT3

Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea

Purity: ≥99%

Product Details
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Biological Activity

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Technical Data

M.Wt:
319.38
Formula:
C14H17N5O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1426152-53-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
    Liu et al.
    J.Med.Chem., 2013;56:2110

Product Datasheets

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