Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Biological ActivityUNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
Liu et al.
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