Methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd
= 3.9 μ
M). Selectively inhibits the L3MBTL13XMBT
-H4K20me1 interaction in a peptide pull down assay.
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Structure-activity relationships of methyl-lysine reader antagonists.
Herold et al.