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UNC 926 hydrochloride

Catalog #: 4516 Datasheet / COA / SDS

Discontinued Product

4516 has been discontinued.
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UNC 926 hydrochloride | CAS No. 1782573-49-2 | Additional Transcription Factor Compounds
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Description: L3MBTL1 domain inhibitor

Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride

Purity: ≥99%

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Biological Activity

UNC 926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.

Technical Data

M.Wt:
373.72
Formula:
C16H21BrN2O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1782573-49-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity relationships of methyl-lysine reader antagonists.
    Herold et al.
    Med.Chem.Comm, 2012;3:45

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