Biological ActivityUrotensin II (human) is a potent endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.
(Modifications: Disulfide bridge between 5 - 10)
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Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord.
Coulouarn et al.
Is urotensin-II the new endothelin?
Maguire and Davenport
Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction.
Nothacker et al.
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