Urotensin II (human)

Name: Urotensin II (human)
Brand: Tocris Bioscience
SKU: 1642

Tocris Bioscience | Catalog # 1642

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Product Documents

Endogenous vasoactive agonist for the UT receptor

Discontinued Product

1642 has been discontinued. View all Urotensin-II Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous vasoactive agonist for the UT receptor

View all Urotensin-II Receptor Agonists »

Product Description

Urotensin II (human) is a potent endogenous peptide agonist for the urotensin-II receptor (EC₅₀ = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.

Product Specifications for Urotensin II (human)

Molecular Weight

1388.57

Formula

C₆₄H₈₅N₁₃O₁₈S₂

Storage

Desiccate at -20°C

CAS Number

251293-28-4

PubChem ID

46225600

InChI Key

HFNHAPQMXICKCF-USJMABIRSA-N

SMILES

[H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Maguire and Davenport Is urotensin-II the new endothelin? Br.J.Pharmacol 2002 PMID: 12381671
Nothacker Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1999 PMID: 10559967
Coulouarn Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9861051

Product Documents for Urotensin II (human)

Certificate of Analysis

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Product Specific Notices for Urotensin II (human)

For research use only

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