Catalog Number: 1642
Biological Activity
Potent endogenous peptide agonist for the urotensin-II receptor (EC50 = 0.1 nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals in vitro and in vivo, effects which vary between species. Also has been shown to mediate bronchoconstriction.
Technical Data
  • M.Wt:
    1388.57
  • Formula:
    C64H85N13O18S2
  • Sequence:
    ETPDCFWKYCV

    (Modifications: Disulfide bridge between 5 - 10)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    251293-28-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord.
    Coulouarn et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:15803
  2. Is urotensin-II the new endothelin?
    Maguire and Davenport
    Br.J.Pharmacol, 2002;137:579
  3. Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction.
    Nothacker et al.
    Nat.Cell.Biol., 1999;1:383

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