(±)-Vesamicol hydrochloride
Chemical Name: (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride
Purity: ≥99%
Biological Activity
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Efange et al.
J.Med.Chem., 1997;40:3905 -
Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats.
Kobayashi et al.
Brain Res.Bull., 1997;43:17 -
Active transport of acetylcholine by the human vesicular acetylcholine transporter.
Varoqui and Erickson
J.Biol.Chem., 1996;271:27229
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