Catalog Number: 0653
Alternate Names: AH 5183
Chemical Name: (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride
Biological Activity
Inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    295.85
  • Formula:
    C17H25NO.HCl
  • Solubility:
    Soluble to 20 mM in ethanol and to 50 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    120447-62-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
    Efange et al.
    J.Med.Chem., 1997;40:3905
  2. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats.
    Kobayashi et al.
    Brain Res.Bull., 1997;43:17
  3. Active transport of acetylcholine by the human vesicular acetylcholine transporter.
    Varoqui and Erickson
    J.Biol.Chem., 1996;271:27229

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