Voglibose
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol
Biological Activity
Voglibose is an orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes.
Matsuo et al.
Am.J.Clin.Nutr., 1992;55:314S -
α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate.
Matsui et al.
Anal.Sci., 2009;25:559 -
Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.
Moritoh et al.
J.Pharmacol.Exp.Ther., 2009;329:669
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