Potent and selective negative allosteric modulator of mGlu1
= 99 nM). Exhibits >100-fold selectivity for mGlu1
and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.
Lovell et al.