Chemical Name:3-[(3R)-3-Methyl-4-(tricyclo[220.127.116.11,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Biological Activity Potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C
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