VU 0469650 hydrochloride

Key Product Details

Product Description

VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu₁ (IC₅₀ = 99 nM). Exhibits >100-fold selectivity for mGlu₁ over mGlu_2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.

Product Specifications for VU 0469650 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0469650 hydrochloride

The following data is based on the product molecular weight 400.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.47 mL	24.94 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lovell N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu₁: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 2013 PMID:  23727046

Product Documents for VU 0469650 hydrochloride