Catalog Number: 0361
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Biological Activity
Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.
Technical Data
  • M.Wt:
    349.27
  • Formula:
    C14H17ClN2O2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    88519-57-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1.
    Bosch et al.
    J.Biol.Chem., 1998;273:22145
  2. Naphthalenesulfonamides as calmodulin antagonists.
    Hidaka and Tanaka
    Methods Enzymol., 1983;102:185
  3. Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13.
    Stroble and Peterson
    J.Pharmacol.Exp.Ther., 1992;263:186

Have you used W-13 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information