Catalog Number: 0361
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Biological Activity
Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1.
    Bosch et al.
    J.Biol.Chem., 1998;273:22145
  2. Naphthalenesulfonamides as calmodulin antagonists.
    Hidaka and Tanaka
    Methods Enzymol., 1983;102:185
  3. Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pimozide and the calmodulin antagonist, W-13.
    Stroble and Peterson
    J.Pharmacol.Exp.Ther., 1992;263:186
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