W-13 hydrochloride
Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity: ≥98%
Biological Activity
W-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1.
Bosch et al.
J.Biol.Chem., 1998;273:22145 -
Naphthalenesulfonamides as calmodulin antagonists.
Hidaka and Tanaka
Methods Enzymol., 1983;102:185 -
Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13.
Stroble and Peterson
J.Pharmacol.Exp.Ther., 1992;263:186
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Citations for W-13 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for W-13 hydrochloride include:
2 Citations: Showing 1 - 2
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Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
Authors: Yanda Et al.
J Biol Chem 2017;292:17897
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Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.
Authors: Sethna Et al.
J Neurosci Res 2016;94:401
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