Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Biological ActivityW-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC50 of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21cip1.
Bosch et al.
Naphthalenesulfonamides as calmodulin antagonists.
Hidaka and Tanaka
Methods Enzymol., 1983;102:185
Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13.
Stroble and Peterson
Citations for W-13 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for W-13 hydrochloride include:
2 Citations: Showing 1 - 2
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
Authors: Yanda Et al.
J Biol Chem 2017;292:17897
Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.
Authors: Sethna Et al.
J Neurosci Res 2016;94:401
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