Catalog Number: 0368
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Biological Activity
Calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).
Technical Data
  • M.Wt:
    342.88
  • Formula:
    C16H22N2O2S.HCl
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in water
  • Storage:
    Store at RT
  • CAS No:
    61714-25-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
    Hidaka et al.
    Proc.Natl.Acad.Sci.U.S.A., 1981;78:4354
  2. Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives.
    Hidaka et al.
    Mol.Pharmacol., 1981;20:571
  3. Naphthalenesulfonamides as calmodulin antagonists.
    Hidaka and Tanaka
    Methods Enzymol., 1983;102:185
Citations:

The citations listed below are publications that use Tocris products. Selected citations for W-5 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    PLoS Biol 2009;284:8726

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