WAY 629 hydrochloride

Catalog # Availability Size / Price Qty
2173/10
2173/50
Cat.No. 2173 - WAY 629 hydrochloride | C15H18N2.HCl | CAS No. 57756-44-2
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Description: Selective 5-HT2C agonist

Chemical Name: 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride

Purity: ≥98%

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Biological Activity

Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.

Technical Data

M.Wt:
262.78
Formula:
C15H18N2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
57756-44-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor.
    Sabb et al.
    Bioorg.Med.Chem.Lett., 2004;14:2603
  2. Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists.
    Dunlop et al.
    Fund.Clin.Pharmacol., 2004;18:145

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