Y-25130 hydrochloride
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Purity: ≥99%
Biological Activity
Y-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist.
Fukuda et al.
Eur.J.Pharmacol., 1991;196:299 -
The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis.
Haga et al.
Jpn.J.Pharmacol., 1993;63:377 -
Antagonistic activity of Y-25130 on 5-HT3 receptors.
Sato et al.
Jpn.J.Pharmacol., 1992;59:443
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Y-25130 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:
2 Citations: Showing 1 - 2
-
Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles.
Authors: Sándor Et al.
Front Pharmacol 2018;9:323
-
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
Authors: Xiao Et al.
Proc Natl Acad Sci U S A 2008;4:12
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for Y-25130 hydrochloride
There are currently no reviews for this product. Be the first to review Y-25130 hydrochloride and earn rewards!
Have you used Y-25130 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
