Catalog Number: 0380
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Biological Activity
A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 10 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis.
    Haga et al.
    Jpn.J.Pharmacol., 1993;63:377
  2. The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist.
    Fukuda et al.
    Eur.J.Pharmacol., 1991;196:299
  3. Antagonistic activity of Y-25130 on 5-HT3 receptors.
    Sato et al.
    Jpn.J.Pharmacol., 1992;59:443

The citations listed below are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
    Authors: Xiao Et al.
    Proc Natl Acad Sci U S A 2008;4:12

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