Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Biological ActivityY-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist.
Fukuda et al.
The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis.
Haga et al.
Antagonistic activity of Y-25130 on 5-HT3 receptors.
Sato et al.
Citations for Y-25130 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:
2 Citations: Showing 1 - 2
Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles.
Authors: Sándor Et al.
Front Pharmacol 2018;9:323
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
Authors: Xiao Et al.
Proc Natl Acad Sci U S A 2008;4:12
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