YM 202074 sesquifumarate
Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate
Purity: ≥99%
Biological Activity
YM 202074 sesquifumarate is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models.
Kohara et al.
Brain Res., 2008;1191:168 -
Metabotropic glutamate 1 receptor: current concepts and perspectives.
Ferraguti et al.
Pharmacol.Rev., 2008;60:536 -
Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1.
Yanamoto et al.
Nucl.Med.Biol., 2010;37:615
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