YM 202074 sesquifumarate

Tocris Bioscience | Catalog # 3413

High affinity, selective mGlu1 antagonist
Tocris Bioscience
Discontinued Product
3413 has been discontinued. View all Group I mGluR Antagonists products.

Key Product Details

Description

High affinity, selective mGlu1 antagonist
View all Group I mGluR Antagonists »

Product Description

YM 202074 sesquifumarate is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.

Product Specifications for YM 202074 sesquifumarate

Molecular Weight

588.67

Formula

C22H30N4O2S.1.5C4H4O4

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate

CAS Number

299900-84-8

PubChem ID

90488842

InChI Key

HABHEZNVNBKOQJ-VQYXCCSOSA-N

SMILES

CN(CCOC)CC1=CC=C2C(N(C=C(C(N(C)C4CCCCC4)=O)S3)C3=N2)=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.CN(CCOC)CC5=CC=C6C(N(C=C(C(N(C)C8CCCCC8)=O)S7)C7=N6)=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.75 20
DMSO 48.75 100

Preparing Stock Solutions for YM 202074 sesquifumarate

The following data is based on the product molecular weight 588.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.70 mL 8.49 mL 16.99 mL
5 mM 0.34 mL 1.70 mL 3.40 mL
10 mM 0.17 mL 0.85 mL 1.70 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for YM 202074 sesquifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for YM 202074 sesquifumarate

For research use only

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