YM 202074 sesquifumarate
Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate
Biological ActivityYM 202074 sesquifumarate is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models.
Kohara et al.
Brain Res., 2008;1191:168
Metabotropic glutamate 1 receptor: current concepts and perspectives.
Ferraguti et al.
Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1.
Yanamoto et al.
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