Catalog Number: 2293
Alternate Names: NSC 309132
Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
Biological Activity
Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.
Technical Data
  • M.Wt:
    228.2
  • Formula:
    C9H12N2O5
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    3690-10-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
    Laliberte et al.
    Cancer Chemother.Pharmacol., 1992;30:7
  2. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
    Ben-Kasus et al.
    Biochem.Pharmacol., 2005;70:121
  3. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
    Naeem et al.
    Cardiovasc.Ther. [Epub ahead of print], 2012;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:

3 Citations: Showing 1 - 3
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  1. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One 2013;8:e72881
  2. DNA methylation mediates the discriminatory power of associative long-term memory in honeybees.
    Authors: Biergans Et al.
    PLoS One 2012;7:e39349
  3. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
    Authors: Trowbridge Et al.
    Gastroenterology 2012;26:344

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