Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50
= 120 μ
M) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki
~ 2 μ
M); induces differentiation of mesenchymal stem cells into cardiomyocytes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
Laliberte et al.
Cancer Chemother.Pharmacol., 1992;30:7
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
Ben-Kasus et al.
DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
Naeem et al.
Cardiovasc.Ther. [Epub ahead of print], 2012;
The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:
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