Zebularine

Key Product Details

Product Description

Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC₅₀ = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (K_i ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Product Specifications for Zebularine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zebularine

The following data is based on the product molecular weight 228.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.38 mL	21.91 mL	43.82 mL
5 mM	0.88 mL	4.38 mL	8.76 mL
10 mM	0.44 mL	2.19 mL	4.38 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Ben-Kasus Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem.Pharmacol. 2005 PMID: 15885659
• Naeem DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc.Ther. [Epub ahead of print]
• Laliberte Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother.Pharmacol. 1992 PMID: 1375134

Product Documents for Zebularine