Zebularine

Catalog # Availability Size / Price Qty
2293/10
Zebularine | CAS No. 3690-10-6 | Methyltransferase Inhibitors
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Description: DNA methyltransferase and cytidine deaminase inhibitor
Alternative Names: NSC 309132

Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone

Purity: ≥99%

Product Details
Citations (4)
Reviews

Biological Activity

Orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:
228.2
Formula:
C9H12N2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
3690-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
    Laliberte et al.
    Cancer Chemother.Pharmacol., 1992;30:7
  2. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
    Ben-Kasus et al.
    Biochem.Pharmacol., 2005;70:121
  3. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
    Naeem et al.
    Cardiovasc.Ther. [Epub ahead of print], 2012;

Product Datasheets

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Citations for Zebularine

The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:

4 Citations: Showing 1 - 4

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