Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone
Biological ActivityZebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
Laliberte et al.
Cancer Chemother.Pharmacol., 1992;30:7
Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
Ben-Kasus et al.
DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
Naeem et al.
Cardiovasc.Ther. [Epub ahead of print], 2012;
Citations for Zebularine
The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:
4 Citations: Showing 1 - 4
The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation.
Authors: Zou Et al.
Front Immunol 2019;10:1950
Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
Authors: Soltoff and Lannon
PLoS One 2013;8:e72881
DNA methylation mediates the discriminatory power of associative long-term memory in honeybees.
Authors: Biergans Et al.
PLoS One 2012;7:e39349
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Authors: Trowbridge Et al.
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