ZK 756326

Key Product Details

Product Description

ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC₅₀ values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α_2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Product Specifications for ZK 756326

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZK 756326

The following data is based on the product molecular weight 429.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.29 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Haskell Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol.Pharmacol. 2006 PMID: 16221874

Product Documents for ZK 756326