Chemical Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
Biological ActivitySelective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
Haskell et al.
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VersaClone cDNA Plasmids
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