Selective, non-peptide CCR8 chemokine receptor agonist (IC50
values are 1.8 and 2.6 μ
M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A
and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
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Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.
Haskell et al.