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ZK 756326

2565 Datasheet / COA / SDS
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2565/10
2565/50
ZK 756326 | CAS No. 1780259-94-0 | Chemokine Receptor Agonists
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Description: Selective, non-peptide CCR8 agonist

Chemical Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride

Purity: ≥99%

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Biological Activity

Selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Technical Data

M.Wt:
429.38
Formula:
C21H28N2O3.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1780259-94-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Mouse CCR8 (NP_031746) VersaClone cDNA

RDC0018

Human CCR8 (NP_005192) VersaClone cDNA

RDC0017

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