ZK 93423 hydrochloride

Key Product Details

Product Description

ZK 93423 hydrochloride is a potent benzodiazepine receptor agonist (IC₅₀ = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABA_A receptors (K_i values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [³H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.

Product Specifications for ZK 93423 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZK 93423 hydrochloride

The following data is based on the product molecular weight 426.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	7.81 mL	39.04 mL	78.08 mL
1.5 mM	1.56 mL	7.81 mL	15.62 mL
3 mM	0.78 mL	3.90 mL	7.81 mL
15 mM	0.16 mL	0.78 mL	1.56 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• File and Baldwin Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 1987 PMID: 3315125
• Cox Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934 J.Med.Chem. 1998 PMID: 9651158
• Stephens Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 1984 PMID: 6089245

Product Documents for ZK 93423 hydrochloride