Potent benzodiazepine receptor agonist (IC50
= 1 nM). Non-selective between α
3- and α
5-subunit containing GABAA
values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3
H]Ro15-1788 binding to human recombinant α
2 and α
2 receptors respectively). Anxiolytic following systemic administration in vivo
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Effects of β-carbolines in animal models of anxiety.
File and Baldwin
Brain Res.Bull., 1987;19:293
Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors.
Stephens et al.
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934
Cox et al.