ZK 93423 hydrochloride
Chemical Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Biological ActivityPotent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of β-carbolines in animal models of anxiety.
File and Baldwin
Brain Res.Bull., 1987;19:293
Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors.
Stephens et al.
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934
Cox et al.
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