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ZLD 1039

Catalog #: 5847 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5847/50
5847/10
ZLD 1039 | CAS No. 1826865-46-6 | EZH2 Inhibitor
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Description: Potent and selective EZH2 inhibitor; orally bioavailable

Chemical Name: 3-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]benzamide

Purity: ≥98%

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Biological Activity

ZLD 1039 is a potent and selective EZH2 inhibitor (IC50 = 5.6 nM). Displays selectivity for EZH2 over a panel of HMTs (inhibition less than 30% at 16 μM). Blocks H3K27 methylation in breast cancer cell lines. Induces tumor regression and metastasis in breast cancer xenograft-bearing mice. Reactivates silenced tumor suppressors in vivo. Orally bioavailable.

Technical Data

M.Wt:
612.8
Formula:
C36H48N6O3
Solubility:
Soluble to 20 mM in DMSO with gentle warming and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1826865-46-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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